To give you my personal experience on the timezone front. I'm in the UK and used to every RollPlay show live, but my situation has changed. I'm no longer unemployed with infinite free time to sink into NA-centric scheduling.
Tastes are a big factor, and while it may not be your thing, the game is immensely popular on its own and was so long before it came to Twitch. But John's Bloodletters YT/Twitch series is absolutely incredible, and I personally put it on par with Swan Song. Bloodletters works so well because every player knows the game so well, and they can focus their creativity - which will come in time with the RollPlay show. Blades can and does thrive on Twitch, but that's without the business need for that to translate to 1,000+ people every time, even though I believe it's fully capable of doing so.
I love Blades and the crew is great, it's my favourite RollPlay show at the moment, but there's definitely something missing. Compared to the Bloodletters, the Last Word feel considerably more shallow (only a potential tick for those of us who watch both) because there's only so many ways you can describe murdering a person for an Assassin crew mission (it can be done well of course), while as a Hawker gang lends itself to more variety just by not being about killing alone.
To the point (in my opinion): The characters of Blades are the interesting part right now, the crew is not, and on top of that assassins are a dull archetype. Whereas the Bloodletters are more economically and socially focused, with murder as a flavour sometimes.
The Last Word are chasing huge targets that are way out of their league with nothing in between (granted it's a rather young show). There's very little beyond the crew themselves that the audience has had a chance to latch onto, sure, we can laugh at the murder, but you can't create interesting relationships and NPCs out of corpses and red puddles.
This thread has made me concerned for the future of Blades, where prior I was just riding the wave and enjoying it. Just putting fresh thoughts to page.