I saw some people picking up on that! I imagine she developed a tolerance for Lotus but her first time on Lure had some lingering effects. But she was also genuinely excited about Carriless's weird ghost thing and the Dimmer Sisters, it's just that the facade of ambivalence dropped.
No, Rune is rather laissez-faire about everything. The only thing she really cares about right now is becoming strong enough to go after Scurlock. She's curious about She-Who-Slays, but not super motivated.
The drug tattoos fade unless I specifically work out a deal for them to be permanent, is my understanding.
Thought of it in the moment, I didn't know anything about the Dimmer Sisters other than John made it sound like people were afraid of them. I wanted Rune to be excited by what people fear. Which is also why she was excited about Carriless's display of weird, terrifying power.