Yeah, I think what worked for Farscape was that usually shows kind of have all this backstory about how everything is already established and blah blah blah. Farscape was pretty much from Crichton's point of view; everything is new, weird, wonderful, and terrifying, and everyone has to explain it to him. Heck, he's a literal rocket scientist and the general, basic science that everyone around him takes for granted just blows his mind.
I think that's also what worked for Star Trek Voyager too because it was all "new frontier" in a very literal sense.
Which is a massive contrast shows like Andromeda, Firefly, Star Trek TOS/TNG/DS9/Enterprise because they all had a developed backstory that you then as a player were supposed to figure out by piecing random one-liners(like how the Borg were kinda introduced the same time as the Romulans in TNG, but weren't seen for like another two seasons I think), so on the one hand, it was still somewhat new and fantastical, but it didn't carry that "first guy to plant a flag here" feel that I think Farscape had. That might just be me. Granted, Farscape did fall into that trope of Sci-Fi/SyFy shows where eventually there's just an ultimate big bad guy/situation that has to be solved with a big bad weapon, but I don't think that did too much damage to the charm of the overall show. Also, Harvey was the boss. I miss him.